by Biostation
バイオステーションポッドキャストは研究やキャリア選択の裏側を可視化することを目指します。
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🇯🇵
Publishing Since
2/22/2022
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March 18, 2025
<p>名古屋大学教授の松本有樹修先生をゲストにお呼びして、翻訳されるノンコーディングRNA、リボソームの多様性、中山敬一ラボでのPhD生活、ハーバード大学Pandolfi研での留学、これからの研究の展望などについてお話をお聞きしました。(収録日2025.03.11)</p><p><br></p><p>Shownotes:</p><p><a href="https://ger.sub.jp/index.html" target="_blank" rel="ugc noopener noreferrer">松本先生ラボHP</a></p><p><a href="https://nakayama-lab.org/" target="_blank" rel="ugc noopener noreferrer">中山敬一先生</a></p><p>中山研での松本先生の論文(p57 <a href="https://www.sciencedirect.com/science/article/pii/S1934590911003298?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">1</a>, <a href="https://ashpublications.org/blood/article/123/22/3429/32541/p57-regulates-T-cell-development-and-prevents" target="_blank" rel="ugc noopener noreferrer">2</a>: Fbx7 <a href="https://www.sciencedirect.com/science/article/pii/S0021925820517547?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">1,</a> <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2011.01851.x" target="_blank" rel="ugc noopener noreferrer">2</a>)</p><p><a href="https://med.stanford.edu/changlab.html" target="_blank" rel="ugc noopener noreferrer">Howard Chang </a></p><p><a href="https://www.sciencedirect.com/science/article/pii/S0092867407006599?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">HOTAIRの論文</a></p><p><a href="https://www.lncrna.io/" target="_blank" rel="ugc noopener noreferrer">John Rinn</a></p><p><a href="https://pierpaolopandolfi.com/" target="_blank" rel="ugc noopener noreferrer">Pier Paolo Pandolfi</a></p><p><a href="https://www.nature.com/articles/nature21034" target="_blank" rel="ugc noopener noreferrer">松本先生のSPARの論文</a></p><p><a href="https://www.nature.com/articles/nature04433" target="_blank" rel="ugc noopener noreferrer">JmjC domain</a></p><p><a href="https://www.nature.com/articles/d41586-025-00217-w" target="_blank" rel="ugc noopener noreferrer">Dark Proteomeと呼ばれている</a></p><p><a href="https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(18)30112-0" target="_blank" rel="ugc noopener noreferrer">Upstream ORFが翻訳されると下流の翻訳が抑制される(の例)</a></p><p><a href="https://academic.oup.com/nar/article/49/13/7298/6312751" target="_blank" rel="ugc noopener noreferrer">翻訳されている位置をより正確に検出する手法</a></p><p><a href="https://academic.oup.com/bioinformatics/article/27/13/i275/178183" target="_blank" rel="ugc noopener noreferrer">PhyloCSF</a></p><p>翻訳されるノンコーディングRNAの論文(<a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009686" target="_blank" rel="ugc noopener noreferrer">TINCR</a>, <a href="https://www.nature.com/articles/s41467-022-28677-y" target="_blank" rel="ugc noopener noreferrer">KastorとPolluks</a>)</p><p><a href="https://ja.wikipedia.org/wiki/%E9%8D%8B%E5%B3%B6%E9%99%BD%E4%B8%80" target="_blank" rel="ugc noopener noreferrer">鍋島陽一先生</a></p><p><a href="https://bio.nikkeibp.co.jp/atcl/report/16/011900001/16/08/24/00054/" target="_blank" rel="ugc noopener noreferrer">Klotho遺伝子</a></p><p><a href="https://www.nature.com/articles/s41586-023-05946-4" target="_blank" rel="ugc noopener noreferrer">C末端の疎水性と分解</a></p><p><a href="https://www.nature.com/articles/s41586-024-07935-7" target="_blank" rel="ugc noopener noreferrer">元根さんのナノポアの論文</a></p><p><a href="https://www.thermofisher.com/order/catalog/product/BRE725660" target="_blank" rel="ugc noopener noreferrer">アストラル(質量分析器)</a></p><p><a href="https://www.igakuken.or.jp/circadian/members.html" target="_blank" rel="ugc noopener noreferrer">吉種先生</a></p><p><a href="https://www.nature.com/articles/s41467-023-37838-6" target="_blank" rel="ugc noopener noreferrer">心筋リボソームの論文</a></p><p><a href="https://www.science.org/doi/10.1126/science.1141915" target="_blank" rel="ugc noopener noreferrer">胸腺プロテアソーム(Thym-Proteasome)</a></p><p><a href="https://www.nature.com/articles/s41586-022-05508-0" target="_blank" rel="ugc noopener noreferrer">精巣特異的リボソーム</a></p><p><a href="https://www.science.org/doi/10.1126/science.adn2623" target="_blank" rel="ugc noopener noreferrer">Maria Barna先生のリボソーム多様性の論文</a></p>
February 3, 2025
<p>David Baker(2024年タンパク質デザインでノーベル化学賞)ラボでポスドクをされています<strong>本田信吾さんをゲスト</strong>にお呼びしました。本田さんはアサヒビールを経て東大野地研で学位を取られ、その後現在のBakerラボに所属されています。今回は本<strong>田さんのこれまでのキャリアからタンパク質デザインの現在、本田さんの現在の研究</strong>などについてお聞きしました。さらに<strong>Bakerラボの雰囲気やシアトルの生活の様子</strong>など研究以外のトピックも盛りだくさんでお届けします。(収録日2025.01.18)</p> <p><br></p> <p>Shownotes:</p> <p><a href="http://www.nojilab.t.u-tokyo.ac.jp/">野地研</a></p> <p><a href="https://pubs.acs.org/doi/10.1021/acs.analchem.0c05360">本田さんの野地研での論文</a></p> <p><a href="http://www.nojilab.t.u-tokyo.ac.jp/research/bioassay/">デジタルバイオアッセイ</a></p> <p><a href="https://wyss.harvard.edu/team/core-faculty/david-walt/">David R. Walt</a></p> <p><a href="https://www.quanterix.com/simoa-technology/">Simoa (Degital ELISA)</a></p> <p><a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.202007477">Alkaline Phosphataseのheterogeneousな画分を検出して診断に応用</a></p> <p><br></p> <p><a href="https://www.bakerlab.org/">David Bakerラボ</a></p> <p><a href="https://www.nature.com/articles/s41586-021-03258-z">プローブのデザイン</a></p> <p><a href="http://www.protein.osaka-u.ac.jp/protein_design/">古賀先生</a> </p> <p><a href="https://msg.ucsf.edu/people/david-agard-phd">David Agard</a></p> <p><a href="https://www.science.org/doi/10.1126/science.1089427">Top7</a></p> <p><a href="https://www.nature.com/articles/nature11600">古賀先生のデザイン原則</a></p> <p><a href="https://researchmap.jp/naoya-kobayashi">NAISTの小林先生</a></p> <p><a href="https://vilyatx.com/">VILYA</a></p> <p><a href="https://www.science.org/doi/10.1126/science.abj8754">RoseTTAFold</a> (Minkyung Baek et al.)</p> <p><a href="https://www.nature.com/articles/s41586-023-06415-8">RFdiffusion</a></p> <p><a href="https://www.science.org/doi/10.1126/science.adl2528">RoseTTAFold All-Atom</a></p> <p><a href="https://www.nature.com/articles/s41586-024-07487-w">AlphaFold 3</a></p> <p><a href="https://www.marktechpost.com/2024/11/17/mit-researchers-propose-boltz-1-the-first-open-source-ai-model-achieving-alphafold3-level-accuracy-in-biomolecular-structure-prediction/">Boltz-1</a></p> <p><a href="https://x.com/jueseph/status/1857013539887546561">Deepmindがenzymologistを募集している</a></p> <p><a href="https://www.biorxiv.org/content/10.1101/2024.08.29.610411v1">Serine hydrolasesのde novoデザイン</a></p> <p><a href="https://ista.ac.at/en/research/praetorius-group/">Florian Praetorius</a></p> <p><a href="https://www.science.org/doi/10.1126/science.abj7662">Danny D. SahtoeとFlorianの論文</a></p> <p><a href="https://www.science.org/doi/10.1126/science.adg7731">DynamicなHingeのデザイン</a></p> <p><a href="https://www.biorxiv.org/content/10.1101/2024.11.15.623900v1">Adam Broermanの論文</a></p> <p><a href="https://deepmind.google/discover/blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/">AlphaProteo</a></p> <p><a href="https://www.biorxiv.org/content/10.1101/2024.09.30.615802v1">BindCraft</a></p> <p><a href="https://www.nature.com/articles/s41586-023-05909-9">Kejia Wuが設計していた</a></p> <p><a href="https://en.wikipedia.org/wiki/Skycovione">De novoデザインタンパク質で作られたCOVID-19ワクチン</a></p> <p><br></p> <p><a href="https://open.spotify.com/show/1QHT8n1yxf9dX0vbjhrMS8">分子デザインはじめました</a></p>
January 16, 2025
<p>今回はワシントン大学セントルイスで2025年から研究室を主宰されている牛木亜紀さんをゲストにお迎えしました。牛木さんは筑波大学・谷本研究室で学位をとられたのち、UCSFのNadav Ahituv先生の研究室でエンハンサーと疾患のかかわりで重要な成果を出されております。今回はこれまでの研究の背景やジョブハント事情、これからの牛木ラボの方向性などについてお聞きししました。(収録日2024.12.29)</p> <p><br></p> <p><a href="https://sites.wustl.edu/ushikilab/" target="_blank" rel="ugc noopener noreferrer">牛木ラボHP</a></p> <p><a href="https://sites.google.com/view/tanimoto-lab" target="_blank" rel="ugc noopener noreferrer">筑波大 谷本研究室</a></p> <p>レニンの論文(<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166974" target="_blank" rel="ugc noopener noreferrer">1</a>, <a href="https://www.tandfonline.com/doi/10.1128/MCB.00566-17" target="_blank" rel="ugc noopener noreferrer">2</a>) <a href="https://www.amazon.co.jp/%E9%80%B2%E5%8C%96%E3%81%97%E3%81%99%E3%81%8E%E3%81%9F%E8%84%B3%E2%80%95%E4%B8%AD%E9%AB%98%E7%94%9F%E3%81%A8%E8%AA%9E%E3%82%8B%E3%80%8C%E5%A4%A7%E8%84%B3%E7%94%9F%E7%90%86%E5%AD%A6%E3%80%8D%E3%81%AE%E6%9C%80%E5%89%8D%E7%B7%9A-%E3%83%96%E3%83%AB%E3%83%BC%E3%83%90%E3%83%83%E3%82%AF%E3%82%B9-%E6%B1%A0%E8%B0%B7-%E8%A3%95%E4%BA%8C/dp/4062575388" target="_blank" rel="ugc noopener noreferrer">進化しすぎた脳</a></p> <p><a href="https://www.amazon.co.jp/%E7%94%9F%E7%89%A9%E3%81%A8%E7%84%A1%E7%94%9F%E7%89%A9%E3%81%AE%E3%81%82%E3%81%84%E3%81%A0-%E8%AC%9B%E8%AB%87%E7%A4%BE%E7%8F%BE%E4%BB%A3%E6%96%B0%E6%9B%B8-%E7%A6%8F%E5%B2%A1-%E4%BC%B8%E4%B8%80/dp/4061498916/ref=sr_1_1?__mk_ja_JP=%E3%82%AB%E3%82%BF%E3%82%AB%E3%83%8A&crid=PIOGC3R7ZDXA&dib=eyJ2IjoiMSJ9.QAy7FyArTro8lsdcBuQczYSfr-beumvESADq6deIVC9vyT03hkCE5-3qkvxyq0ViGFwVni--0QSmR6erBPjiYiqi4kOw45I3vx6ypknaRBEOTFejT3lB8GxZFIlrzCWzqbO6iDwK0P9-S0qvLqXwBRMsoG4q2mJZFp_bSVp_-dAHe96J3av9VP1MovAcwAPEp_BH_wPHgeefrFQtHp7jwaZsvbFlgERzVI9Dbt2WJf_JvjKHfOyoFWSrepkNoj6PknjuWWWLL8FLf9nlZEO4JuxxIzEz8mHZdN0-GA6ntrrNvTUbToEiLIQsw1kzd8tBktbAhSwdkSS9COr4_VoyuA.uDcuEei7GLu76a_2xgelugZ0Pi_kb50p0-2LKy_uWho&dib_tag=se&keywords=%E7%94%9F%E7%89%A9%E3%81%A8%E7%84%A1%E7%94%9F%E7%89%A9%E3%81%AE%E9%96%93&qid=1737005059&s=books&sprefix=%E7%94%9F%E7%89%A9%E3%81%A8%E7%84%A1%E7%94%9F%E7%89%A9%E3%81%AE%E9%96%93%2Cstripbooks%2C117&sr=1-1" target="_blank" rel="ugc noopener noreferrer">生物と無生物のあいだ</a></p> <p><a href="https://www.amazon.co.jp/%E3%83%9F%E3%83%88%E3%82%B3%E3%83%B3%E3%83%89%E3%83%AA%E3%82%A2%E3%83%BB%E3%83%9F%E3%82%B9%E3%83%86%E3%83%AA%E3%83%BC%E2%80%95%E9%A9%9A%E3%81%8F%E3%81%B9%E3%81%8D%E7%B4%B0%E8%83%9E%E5%B0%8F%E5%99%A8%E5%AE%98%E3%81%AE%E5%83%8D%E3%81%8D-%E3%83%96%E3%83%AB%E3%83%BC%E3%83%90%E3%83%83%E3%82%AF%E3%82%B9-%E6%9E%97-%E7%B4%94%E4%B8%80/dp/4062573911/ref=sr_1_1?__mk_ja_JP=%E3%82%AB%E3%82%BF%E3%82%AB%E3%83%8A&crid=2KZ2L8Z38SK4W&dib=eyJ2IjoiMSJ9.3I3r7KkGVlI8rfD9litcCaQtLAIxVNj7tcjO9h9uYPg_gFVq2MdecTZLLj3uhg4EEoXmNZ1GR2jwMs3qO8OfuMr0v6HqzDYj6AONzcIah7ezh_V1esVtnV1aW0zclMtC4p7EP37misFjG9HrhO4P7gktmtIGQyaOa2BZVOEcd-jraAacDn9viYBPHHqDCicO_AYI8rwuuV2qBTqrDc6oa9PDzfM1lab2gbwpHk7dThQ.g7qS9SSHlLcRnfv84s8lIKVx3_Yj7TfNsepJsEXlwGc&dib_tag=se&keywords=%E3%83%9F%E3%83%88%E3%82%B3%E3%83%B3%E3%83%89%E3%83%AA%E3%82%A2%E3%83%BB%E3%83%9F%E3%82%B9%E3%83%86%E3%83%AA%E3%83%BC&qid=1737005088&s=books&sprefix=%E3%83%9F%E3%83%88%E3%82%B3%E3%83%B3%E3%83%89%E3%83%AA%E3%82%A2+%E3%83%9F%E3%82%B9%E3%83%86%E3%83%AA%E3%83%BC%2Cstripbooks%2C77&sr=1-1" target="_blank" rel="ugc noopener noreferrer">ミトコンドリア・ミステリー</a></p> <p><br></p> <p><a href="https://pharm.ucsf.edu/ahituv" target="_blank" rel="ugc noopener noreferrer">Nadav Ahituvラボ</a></p> <p>牛木さんの<a href="https://www.nature.com/articles/s41467-021-22470-z" target="_blank" rel="ugc noopener noreferrer">無手足性の論文</a></p> <p>牛木さんの<a href="https://www.sciencedirect.com/science/article/pii/S2211124724002353?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">側弯症の論文</a></p> <p><br></p> <p><a href="https://sites.google.com/view/inouelabwebsite/home" target="_blank" rel="ugc noopener noreferrer">井上詞貴先生</a></p> <p><a href="https://www.sciencedirect.com/science/article/pii/S0092867416313101" target="_blank" rel="ugc noopener noreferrer">ヘビのCell</a></p> <p><a href="https://dna.lbl.gov/" target="_blank" rel="ugc noopener noreferrer">Len Pennacchio, Axel Visel</a></p>
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