by NeuroRadio
米国シアトル・ボストン在住の神経科学者2人によるポッドキャスト。 最新の研究論文紹介や基礎科学・医学研究に関する(あるいは全く関係しない)雑談、留学情報など。 感想やコメント、質問などはtwitterハッシュタグ #NeuroRadio あるいはinfoあっとneuroradio.tokyoまで。
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April 17, 2025
<p>予算カット、２年ルールWaiver、資産運用への影響、メールでのコミュニケーションなど。論文紹介は、実装が簡単な高速FLIMと、Sequeincing by expansion (4/9収録)</p><p><br></p><p>Show Notes (<a href="http://neuroradio.tokyo/2025/04/17/88-absolutely-not-absolute/" target="_blank" rel="noopener noreferer">番組HP</a>):</p><ul><li><p><a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/gdvznjkykvw/harvard_lawsuit.pdf" target="_blank" rel="ugc noopener noreferrer">渦中のハーバード(pdf)</a></p></li><li><p><a href="https://www.science.org/content/article/nih-freezes-all-research-grants-columbia-university" target="_blank" rel="ugc noopener noreferrer">コロンビアのNIHグラント停止</a></p></li><li><p><a href="https://www.harvard.edu/president/news/2025/financial-stewardship/" target="_blank" rel="ugc noopener noreferrer">Hiring Freeze Announcement</a></p></li><li><p><a href="https://www.theguardian.com/us-news/2025/apr/10/how-many-student-visas-revoked" target="_blank" rel="ugc noopener noreferrer">デモに参加したらビザ停止</a></p></li><li><p><a href="https://standupforscience2025.org/" target="_blank" rel="ugc noopener noreferrer">Stand Up For Science</a></p></li><li><p><a href="https://x.com/NeuroRadio_/status/1892294816295161905" target="_blank" rel="ugc noopener noreferrer">Twitterで告知</a></p></li><li><p><a href="https://www.us.emb-japan.go.jp/itpr_ja/j-visa.html" target="_blank" rel="ugc noopener noreferrer">2年ルールのWaiver</a></p></li><li><p><a href="https://neuroradio.tokyo/2025/01/07/84-synthetic-developmental-biology/" target="_blank" rel="ugc noopener noreferrer">濱崎さん回</a></p></li><li><p><a href="https://www.nomura.co.jp/terms/english/other/A02989.html" target="_blank" rel="ugc noopener noreferrer">401(k)</a></p></li><li><p><a href="https://www.resonabank.co.jp/nenkin/ideco/column/what-is-401k.html" target="_blank" rel="ugc noopener noreferrer">iDeCo</a></p></li><li><p>Reddit: <a href="https://www.reddit.com/r/financialindependence/comments/16xymii/fire_flow_chart_version_43/?rdt=49040" target="_blank" rel="ugc noopener noreferrer">Fire Flow Chart Version 4.3</a></p></li><li><p>Reddit: <a href="https://www.reddit.com/r/FinancialPlanning/comments/185u6za/401k_max_vs_mortgage_payment/" target="_blank" rel="ugc noopener noreferrer">401(k) max vs mortgage payment</a></p></li><li><p><a href="https://www.y-history.net/appendix/wh1102-044.html" target="_blank" rel="ugc noopener noreferrer">三権分立の憲法への反映はアメリカが先</a></p></li><li><p>五十嵐さん回 <a href="https://neuroradio.tokyo/2021/09/15/23-poor-is-the-pupil-who-does-not-surpass-his-master-part-1/" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://neuroradio.tokyo/2021/09/22/24-25-poor-is-the-pupil-who-does-not-surpass-his-master-part-2-3/" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://neuroradio.tokyo/2021/10/08/26-poor-is-the-pupil-who-does-not-surpass-his-master-part-4/" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://neuroradio.tokyo/2024/07/14/76-getting-out-of-the-comfort-zone/" target="_blank" rel="ugc noopener noreferrer">4</a></p></li><li><p><a href="https://www.nature.com/articles/d41586-025-01098-9" target="_blank" rel="ugc noopener noreferrer">NSFはFellowshipを出す数が半分に</a></p></li><li><p><a href="https://www.reddit.com/r/biotech/comments/z11o8w/comment/ixf6dlo/" target="_blank" rel="ugc noopener noreferrer">Redditに降臨</a></p></li><li><p><a href="https://sites.google.com/site/akihiroumezawa/storage/liu-zette-shuida" target="_blank" rel="ugc noopener noreferrer">２ちゃんに柳沢先生ご本人登場</a></p></li><li><p><a href="https://www.science.org/content/article/mouse-mammoth-s-pelt-makes-superfuzzy-debut" target="_blank" rel="ugc noopener noreferrer">マウスも毛むくじゃらに</a></p></li><li><p>の<a href="https://www.biorxiv.org/content/10.1101/2025.03.03.641227v1" target="_blank" rel="ugc noopener noreferrer">プレプリント</a></p></li><li><p><a href="https://colossal.com/direwolf/" target="_blank" rel="ugc noopener noreferrer">狼復活</a></p></li></ul><p>論文紹介</p><ul><li><p>論文１：<a href="https://www.biorxiv.org/content/10.1101/2025.01.10.632162v1.full" target="_blank" rel="ugc noopener noreferrer">Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution</a></p></li><li><p><a href="https://sabatini.hms.harvard.edu/" target="_blank" rel="ugc noopener noreferrer">Sabatini (弟) ラボ</a></p></li><li><p><a href="https://neuroradio.tokyo/2022/06/22/39-a-biophysicist-turned-neuroscientist/" target="_blank" rel="ugc noopener noreferrer">安田さん回</a></p></li><li><p><a href="https://en.wikipedia.org/wiki/Jablonski_diagram" target="_blank" rel="ugc noopener noreferrer">Jablonski図</a></p></li><li><p><a href="https://www.picoquant.com/dl_manuals/PicoHarp330_Manual.pdf" target="_blank" rel="ugc noopener noreferrer">Time DomainでのFLIM計測のわかりやすい図 (pdf, これの7ページ目)</a></p></li><li><p><a href="https://www.jst.go.jp/pr/announce/20210102/pdf/20210102.pdf" target="_blank" rel="ugc noopener noreferrer">Frequency Domainとの比較に使った図 (pdf)</a></p></li><li><p>注:PMTからのシグナルも位相をズラすと返答してしまっていますが間違いです。(萩)</p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(14)00659-X" target="_blank" rel="ugc noopener noreferrer">Fiber Photometry を流行らせたのはDラボ</a></p></li><li><p><a href="https://www.toyo.co.jp/material/casestudy/detail/LIA" target="_blank" rel="ugc noopener noreferrer">ロックインアンプ</a></p></li><li><p><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122513" target="_blank" rel="ugc noopener noreferrer">FLIM用のcAMPセンサー</a></p></li><li><p><a href="https://sites.wustl.edu/yaochenlab/" target="_blank" rel="ugc noopener noreferrer">Wash UのYao Chen</a></p></li><li><p><a href="https://www.science.org/doi/10.1126/sciadv.adi0643" target="_blank" rel="ugc noopener noreferrer">CholinergicセンサーFLIM転用</a></p></li><li><p><a href="https://www.becker-hickl.com/applications/classic-tcspc/" target="_blank" rel="ugc noopener noreferrer">Becker & HicklのFLIM</a></p></li><li><p><a href="https://opg.optica.org/optica/fulltext.cfm?uri=optica-8-6-885&id=451877" target="_blank" rel="ugc noopener noreferrer">Instant FLIM</a></p></li><li><p><a href="https://neuroradio.tokyo/2024/12/21/83-emo/" target="_blank" rel="ugc noopener noreferrer">前にSabatiniラボのプレプリントを読んだ回</a></p></li><li><p>David AndersonのState論文、たとえば <a href="https://www.cell.com/cell/fulltext/S0092-8674(18)30361-1" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.nature.com/articles/s41586-020-2995-0" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.cell.com/neuron/fulltext/S0896-6273(21)00995-8" target="_blank" rel="ugc noopener noreferrer">3</a></p></li><li><p><a href="https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00210-1/abstract" target="_blank" rel="ugc noopener noreferrer">脳の温度は結構変わる</a></p></li><li><p><a href="https://academic.oup.com/brain/article/146/6/2431/7056579" target="_blank" rel="ugc noopener noreferrer">pHも睡眠とかで変わる</a></p></li><li><p><a href="https://neuroradio.tokyo/2025/01/13/85-prediction-models/" target="_blank" rel="ugc noopener noreferrer">未来予想回</a></p></li><li><p>齋藤さん回 <a href="https://neuroradio.tokyo/2022/07/19/40-casting-light-on-the-life-at-broad-institute-part-1/" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://neuroradio.tokyo/2022/07/25/41-casting-light-on-the-life-at-broad-institute-part-2/" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://neuroradio.tokyo/2024/09/15/79-the-wizard-of-fz/" target="_blank" rel="ugc noopener noreferrer">3</a></p></li><li><p>論文２：<a href="https://www.biorxiv.org/content/10.1101/2025.02.19.639056v2" target="_blank" rel="ugc noopener noreferrer">Sequencing by Expansion (SBX) – a novel, high-throughput single-molecule sequencing technology</a></p></li><li><p><a href="https://www.nature.com/articles/s41587-021-01108-x" target="_blank" rel="ugc noopener noreferrer">ナノポアレビュー</a></p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(01)00515-3" target="_blank" rel="ugc noopener noreferrer">Dpo4</a></p></li><li><p><a href="https://www.pnas.org/doi/abs/10.1073/pnas.1601782113" target="_blank" rel="ugc noopener noreferrer">CMOSによる並列化の例</a></p></li><li><p><a href="https://nanoporetech.com/platform/technology" target="_blank" rel="ugc noopener noreferrer">ONTのNanopore</a></p></li><li><p><a href="https://www.csbj.org/article/S2001-0370(23)00136-8/fulltext" target="_blank" rel="ugc noopener noreferrer">ONTを使ったリード精度benchmark研究</a></p></li><li><p><a href="https://www.basel.com/en/attractions/roche-towers-1f4d756da1" target="_blank" rel="ugc noopener noreferrer">階段状の建物</a></p></li><li><p><a href="https://rd.iai.osaka-u.ac.jp/ja/e6b704cb0f09d00a.html" target="_blank" rel="ugc noopener noreferrer">元根さん</a></p></li><li><p><a href="https://www.nature.com/articles/s41586-024-07935-7" target="_blank" rel="ugc noopener noreferrer">Protein Sequencing</a></p></li><li><p><a href="https://www.pssj.jp/archives/essay/Es_15/Es_15.html" target="_blank" rel="ugc noopener noreferrer">日本語解説</a></p></li><li><p><a href="https://sequencing.roche.com/us/en/article-listing/sequencing-platform-technologies.html" target="_blank" rel="ugc noopener noreferrer">本社のプレスリリース</a></p></li><li><p><a href="https://www.youtube.com/watch?v=G8ECt04qPos" target="_blank" rel="ugc noopener noreferrer">動画</a></p></li></ul><p>Editorial Notes:</p><ul><li><p>The Apprentice の参加者になった気分です (脇)</p></li><li><p>大学の自治を守るのは大変重要ですが、ファカルティは大学側の政府への抗議をどう受け取ってるんでしょう。しかし、9 billionだったり2.2 billionだったり、桁が大き過ぎてもうよくわからなくなってきました(萩)</p></li></ul>
April 6, 2025
<p>Baylor College of Medicineの山本慎也さんがゲスト。後編。ハエの疾患モデルとしての限界、凍結保存ができない問題とそれが育んだコラボレーション文化、留学を選択肢と考えるための本の執筆、PhDを取った機関でポスドクを飛ばしてPIになることについて (3/28収録)</p><p>Show Notes (<a href="http://neuroradio.tokyo/2025/04/07/87-pushing-the-limits-of-drosophila-part-2/" target="_blank" rel="noopener noreferer">番組HP</a>):</p><ul><li><p>山本さんNR回 <a href="https://neuroradio.tokyo/2025/04/02/86-pushing-the-limits-of-drosophila-part-1/" target="_blank" rel="ugc noopener noreferrer">前編</a></p></li><li><p><a href="https://www.nature.com/articles/s41576-023-00633-6" target="_blank" rel="ugc noopener noreferrer">非哺乳類モデル動物の臨床応用</a></p></li><li><p><a href="https://flybase.org/lists/FBhh/" target="_blank" rel="ugc noopener noreferrer">ハエの疾患モデル一覧</a></p></li><li><p><a href="https://www.nature.com/articles/35006074" target="_blank" rel="ugc noopener noreferrer">パーキンソン病モデルハエの例(α-Synuclein)</a></p></li><li><p><a href="https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/neuro.04.005.2009/full" target="_blank" rel="ugc noopener noreferrer">ハエの脳にはドーパミン作動性ニューロンが数百個しかない</a> (Table 1にHemisphereあたり~282個と書いてあるので成虫の脳で550個くらいみたいです。by山)</p></li><li><p><a href="https://www.pnas.org/doi/10.1073/pnas.0400895101" target="_blank" rel="ugc noopener noreferrer">アルツハイマー病モデルハエの例(Aβ42)</a></p></li><li><p>自閉症モデルハエに関するReview <a href="https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.00987/full" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://journals.biologists.com/dmm/article/12/5/dmm039180/3372/Intellectual-disability-and-autism-spectrum" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.mdpi.com/1422-0067/20/17/4071" target="_blank" rel="ugc noopener noreferrer">3</a></p></li><li><p><a href="https://www.nature.com/articles/nrn3567" target="_blank" rel="ugc noopener noreferrer">ハエの求愛行動</a></p></li><li><p><a href="https://psycnet.apa.org/record/2015-40281-001" target="_blank" rel="ugc noopener noreferrer">ハエの攻撃行動</a></p></li><li><p><a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1601-183X.2011.00740.x" target="_blank" rel="ugc noopener noreferrer">ハエのパーソナルスペース</a></p></li><li><p><a href="https://elifesciences.org/articles/02951" target="_blank" rel="ugc noopener noreferrer">ハエのグルーミング</a></p></li><li><p><a href="https://simpson.mcdb.ucsb.edu/" target="_blank" rel="ugc noopener noreferrer">Julie Simpson</a></p></li><li><p><a href="https://link.springer.com/article/10.1007/BF01350033" target="_blank" rel="ugc noopener noreferrer">ハエの嗅覚と痛覚を介した記憶のT-mazeアッセイ</a></p></li><li><p>ハエで精神疾患モデルは作れるか？ <a href="https://www.sciencedirect.com/science/article/abs/pii/S0361923011002802" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://link.springer.com/chapter/10.1007/7854_2010_110" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p><a href="https://www.cell.com/developmental-cell/fulltext/S1534-5807(15)00143-4" target="_blank" rel="ugc noopener noreferrer">ハエのがんモデルでcachexiaが起こる</a></p></li><li><p><a href="https://www.sciencedirect.com/science/article/pii/S1084952114001074" target="_blank" rel="ugc noopener noreferrer">ハエのBMP(Bone Morphogenetic Protein)シグナリング</a></p></li><li><p><a href="https://www.annualreviews.org/content/journals/10.1146/annurev.ento.50.071803.130404" target="_blank" rel="ugc noopener noreferrer">ハエのノルアドレナリン受容体はタイラミンやオクトパミンに反応する</a></p></li><li><p>手間がかかるので誰もやってないハエの凍結保存プロトコル <a href="https://www.nature.com/articles/345170a0" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.science.org/doi/10.1126/science.1470915" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.nature.com/articles/s41467-021-22694-z" target="_blank" rel="ugc noopener noreferrer">3</a></p></li><li><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10116490/" target="_blank" rel="ugc noopener noreferrer">ハエ系統の自由なやりとりの伝統と現状</a></p></li><li><p><a href="https://bdsc.indiana.edu/" target="_blank" rel="ugc noopener noreferrer">Indiana大学のBloomington Drosophila Stock Center</a></p></li><li><p><a href="https://www.dgrc.kit.ac.jp/ja/" target="_blank" rel="ugc noopener noreferrer">京都工繊大のストックセンター</a></p></li><li><p><a href="https://shigen.nig.ac.jp/fly/nigfly/" target="_blank" rel="ugc noopener noreferrer">遺伝研のストックセンター</a></p></li><li><p><a href="https://shop.vbc.ac.at/vdrc_store/" target="_blank" rel="ugc noopener noreferrer">ウィーンのストックセンター</a></p></li><li><p><a href="https://www.ou.edu/journals/dis/" target="_blank" rel="ugc noopener noreferrer">Drosophila Information Service</a></p></li><li><p><a href="https://flybase.org/" target="_blank" rel="ugc noopener noreferrer">FlyBase</a></p></li><li><p><a href="https://www.janelia.org/lab/rubin-lab/our-research/gal4-driver-lines/split-gal4-lines" target="_blank" rel="ugc noopener noreferrer">JaneliaのSplit GAL4リソース</a> <a href="https://splitgal4.janelia.org/cgi-bin/splitgal4.cgi" target="_blank" rel="ugc noopener noreferrer">データベース</a></p></li><li><p><a href="https://www.science.org/doi/10.1126/science.287.5461.2185" target="_blank" rel="ugc noopener noreferrer">ハエゲノムプロジェクト</a>(2000年にドラフトが完成、線虫は<a href="https://www.science.org/doi/10.1126/science.282.5396.2012" target="_blank" rel="ugc noopener noreferrer">1998年</a>でした。by 山)</p></li><li><p><a href="https://www.yodosha.co.jp/yodobook/book/9784758122733/" target="_blank" rel="ugc noopener noreferrer">羊土社から出した『研究留学実践ガイド』</a></p></li><li><p><a href="https://www.yodosha.co.jp/jikkenigaku/study_abroad.html" target="_blank" rel="ugc noopener noreferrer">連載、研究留学の技法２０２３</a></p></li><li><p><a href="https://www.yodosha.co.jp/jikkenigaku/" target="_blank" rel="ugc noopener noreferrer">実験医学</a>：羊土社から刊行されている雑誌。現行。</p></li><li><p><a href="https://ci.nii.ac.jp/ncid/AN00069897" target="_blank" rel="ugc noopener noreferrer">細胞工学</a>: 学研メディカルから刊行されていた雑誌。廃刊。</p></li><li><p><a href="https://ci.nii.ac.jp/ncid/AN00140437" target="_blank" rel="ugc noopener noreferrer">蛋白質・核酸・酵素</a>: 共立出版から刊行されていた雑誌。廃刊。</p></li><li><p>たまたま取れたNotchの特殊なmutationに着目した<a href="https://www.science.org/doi/10.1126/science.1228745" target="_blank" rel="ugc noopener noreferrer">Science</a>論文 日本語での<a href="https://first.lifesciencedb.jp/archives/6389" target="_blank" rel="ugc noopener noreferrer">要約</a></p></li><li><p><a href="https://www.nature.com/articles/43191" target="_blank" rel="ugc noopener noreferrer">NotchはDeltaとJagged(ハエではSerrate)というリガンドを見分けている</a>(訂正：FringeはNotchのDeltaとの結合を強め、Jagged/Serrateとの結合を弱めます。by山)</p></li><li><p>News & Hot Paper Digestではなく、<a href="https://www.yodosha.co.jp/yodobook/book/9784758100953/" target="_blank" rel="ugc noopener noreferrer">カレント・トピックス</a>でした(by 山)</p></li><li><p><a href="https://www.thenotchmeeting.org/" target="_blank" rel="ugc noopener noreferrer">The Notch Meeting</a></p></li><li><p><a href="https://www.grc.org/" target="_blank" rel="ugc noopener noreferrer">Gordon Research Conference(GRC)とGordon Research Seminar(GRS)</a></p></li><li><p><a href="https://www.grc.org/notch-signaling-in-development-regeneration-and-disease-grs-conference/" target="_blank" rel="ugc noopener noreferrer">NotchのGRS</a></p></li><li><p><a href="https://www.yodosha.co.jp/jikkenigaku/book/9784758101332/index.html" target="_blank" rel="ugc noopener noreferrer">GRSの座長をした際の体験談(Campus & Conference探訪記)</a></p></li><li><p><a href="https://www.yodosha.co.jp/yodobook/book/9784758101486/" target="_blank" rel="ugc noopener noreferrer">実験医学のNotchシグナル特集</a></p></li><li><p>どうする？コロナ禍での海外研究留学 <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=67800" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=67900" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=68000" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=68100" target="_blank" rel="ugc noopener noreferrer">4</a> <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=68200" target="_blank" rel="ugc noopener noreferrer">5</a> </p></li><li><p>日本における雇い止め問題に関する<a href="https://www.nature.com/articles/d41586-022-01935-1" target="_blank" rel="ugc noopener noreferrer">Nature</a>と<a href="https://www.science.org/content/article/mass-layoff-looms-japanese-researchers" target="_blank" rel="ugc noopener noreferrer">Science</a>の記事</p></li><li><p><a href="https://ja.wikipedia.org/wiki/%E3%83%99%E3%82%A4%E3%83%A9%E3%83%BC%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6" target="_blank" rel="ugc noopener noreferrer">ベイラー医科大学って知っていますか？</a></p></li><li><p><a href="https://www.nasa.gov/johnson/" target="_blank" rel="ugc noopener noreferrer">ヒューストンのNASAはロケットを打ち上げてない</a></p></li><li><p>『研究留学実践ガイド』のテーマ：<a href="https://www.yodosha.co.jp/bookdata/9784758122733/9784758122733_preface.pdf" target="_blank" rel="ugc noopener noreferrer">はじめに(pdf)</a></p></li><li><p>留学特集の座談会記事 <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=44300" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.yodosha.co.jp/jikkenigaku/articles/index.html?ci=61400" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p><a href="https://www.bcm.edu/people-search/daisuke-nakada-27435" target="_blank" rel="ugc noopener noreferrer">中田大介先生</a></p></li><li><p><a href="https://neuroradio.tokyo/2022/06/22/39-a-biophysicist-turned-neuroscientist/" target="_blank" rel="ugc noopener noreferrer">安田先生NR回</a></p></li><li><p>五十嵐先生NR回 <a href="https://neuroradio.tokyo/2021/09/15/23-poor-is-the-pupil-who-does-not-surpass-his-master-part-1/" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://neuroradio.tokyo/2021/09/22/24-25-poor-is-the-pupil-who-does-not-surpass-his-master-part-2-3/" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://neuroradio.tokyo/2021/10/08/26-poor-is-the-pupil-who-does-not-surpass-his-master-part-4/" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://neuroradio.tokyo/2024/07/14/76-getting-out-of-the-comfort-zone/" target="_blank" rel="ugc noopener noreferrer">4</a></p></li><li><p>留学前後・ラボでの立ち居振る舞い：立ち読みサンプル <a href="https://www.yodosha.co.jp/booksample_img/9784758122733/9784758122733_01.jpg" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.yodosha.co.jp/booksample_img/9784758122733/9784758122733_02.jpg" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p>失敗したけど、こうして切り抜けましたエピソード：特に<a href="https://www.yodosha.co.jp/yodobook/book/9784758122733/" target="_blank" rel="ugc noopener noreferrer">コラム4-5から4-8</a></p></li><li><p>ラボレポート、<a href="https://www.yodosha.co.jp/jikkenigaku/lab.html" target="_blank" rel="ugc noopener noreferrer">留学編</a>・<a href="https://www.yodosha.co.jp/jikkenigaku/labdokuritsu.html" target="_blank" rel="ugc noopener noreferrer">独立編</a></p></li><li><p>留学をしないという「選択肢」：<a href="https://www.yodosha.co.jp/yodobook/book/9784758122733/" target="_blank" rel="ugc noopener noreferrer">コラム4-10</a></p></li><li><p><a href="https://neuroradio.tokyo/2023/04/14/55-and-your-mouse-can-sing/" target="_blank" rel="ugc noopener noreferrer">藤島さんNR回</a> コラム3-3(<a href="https://www.yodosha.co.jp/booksample_img/9784758122733/9784758122733_06.jpg" target="_blank" rel="ugc noopener noreferrer">立ち読みサンプル</a>) </p></li><li><p><a href="https://www.whitehouse.gov/presidential-actions/2025/01/ending-radical-and-wasteful-government-dei-programs-and-preferencing/" target="_blank" rel="ugc noopener noreferrer">DEI政策の激変</a></p></li><li><p><a href="https://compliance.utexas.edu/sb17" target="_blank" rel="ugc noopener noreferrer">テキサスはDEI停止を先取り</a></p></li><li><p><a href="https://en.wikipedia.org/wiki/Students_for_Fair_Admissions_v._Harvard" target="_blank" rel="ugc noopener noreferrer">ハーバードにおけるAffirmative Action訴訟</a></p></li><li><p><a href="https://www.texaschildrens.org/" target="_blank" rel="ugc noopener noreferrer">Texas Children’s Hospital</a></p></li><li><p><a href="https://www.texaschildrens.org/duncan-nri/faculty" target="_blank" rel="ugc noopener noreferrer">Duncan NRI(faculty list)</a></p></li><li><p><a href="https://www.hhmi.org/scientists/huda-y-zoghbi" target="_blank" rel="ugc noopener noreferrer">Huda Zoghbi(HHMI)</a></p></li><li><p><a href="https://www.nature.com/articles/ng1099_185" target="_blank" rel="ugc noopener noreferrer">Rett Syndrome</a></p></li><li><p><a href="https://www.nature.com/articles/ng0894-513" target="_blank" rel="ugc noopener noreferrer">SCA1(Ataxin)</a></p></li><li><p><a href="https://www.nature.com/articles/36579" target="_blank" rel="ugc noopener noreferrer">Atoh1(Math1)</a></p></li><li><p><a href="https://commonfund.nih.gov/earlyindependence" target="_blank" rel="ugc noopener noreferrer">DP5(Early Independence Award)</a></p></li><li><p><a href="https://nexus.od.nih.gov/all/2021/11/18/long-term-trends-in-the-age-of-principal-investigators-supported-for-the-first-time-on-nih-r01-awards/" target="_blank" rel="ugc noopener noreferrer">独立して最初のR01が取れたPIの平均年齢は43歳(2010年 NIH調べ)</a></p></li><li><p><a href="https://www.hhmi.org/scientists/hugo-j-bellen" target="_blank" rel="ugc noopener noreferrer">Hugo Bellen(元HHMI)</a></p></li><li><p>博士の時にやったスクリーニングからプロジェクトがたくさん生まれた <a href="https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(14)01113-1" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.cell.com/cell/fulltext/S0092-8674(14)01589-X" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001777" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001438" target="_blank" rel="ugc noopener noreferrer">4</a> <a href="https://rupress.org/jcb/article/200/6/807/37335/The-C8ORF38-homologue-Sicily-is-a-cytosolic" target="_blank" rel="ugc noopener noreferrer">5</a> <a href="https://elifesciences.org/articles/03558" target="_blank" rel="ugc noopener noreferrer">6</a> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002197" target="_blank" rel="ugc noopener noreferrer">7</a> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001847" target="_blank" rel="ugc noopener noreferrer">8</a> <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002103" target="_blank" rel="ugc noopener noreferrer">9</a> <a href="https://www.cell.com/developmental-cell/fulltext/S1534-5807(15)00828-X" target="_blank" rel="ugc noopener noreferrer">10</a> etc </p></li><li><p><a href="https://socfell.fas.harvard.edu/about" target="_blank" rel="ugc noopener noreferrer">ハーバード</a>、<a href="https://fellows.ucsf.edu/" target="_blank" rel="ugc noopener noreferrer">UCSF</a>、<a href="https://www.janelia.org/inside-look-fellows" target="_blank" rel="ugc noopener noreferrer">Janelia</a>のフェロー制度</p></li><li><p>ドーパミンの産生・放出・代謝
April 2, 2025
<p>Baylor College of Medicineの山本慎也さんがゲスト。前編。ツールとしてハエを使うNeuroscientistと脳を見ているハエGeneticistの違い、ハエForward geneticsからヒト希少疾患研究に繋がった経緯、Living test tubeとしてのハエの魅力、Reverse geneticsによるヒト化ハエのRare disease・Common disease・感染症研究への応用について (3/28収録)</p><p><br></p><p>Show Notes (<a href="https://neuroradio.tokyo/2025/04/02/86-pushing-the-limits-of-drosophila-part-1/" target="_blank" rel="noopener noreferer">番組HP</a>):</p><ul><li><p><a href="https://www.yamamotoflylab.org/" target="_blank" rel="ugc noopener noreferrer">山本さんラボHP</a>(更新が滞りがち) <a href="https://www.linkedin.com/in/shinya-yamamoto-bb1928a0" target="_blank" rel="ugc noopener noreferrer">LinkedIn</a></p></li><li><p><a href="https://www.bcm.edu/" target="_blank" rel="ugc noopener noreferrer">ベイラー医科大学</a></p></li><li><p><a href="https://webpark1297.sakura.ne.jp/wp/" target="_blank" rel="ugc noopener noreferrer">動物育種繁殖学教室</a></p></li><li><p><a href="https://www.u-tokai.ac.jp/facultyguide/faculty/4330/" target="_blank" rel="ugc noopener noreferrer">今川和彦先生</a></p></li><li><p><a href="https://www.mdpi.com/2076-2615/14/14/2077" target="_blank" rel="ugc noopener noreferrer">着床現象は種特異的</a></p></li><li><p>臍帯形成などに異常があるVps26a(Hβ58)の変異マウス <a href="https://journals.biologists.com/dev/article-abstract/111/3/801/36748/H-58-an-insertional-mutation-affecting-early" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://journals.biologists.com/dev/article-abstract/115/1/277/37443/Identification-and-characterization-of-a-novel" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p><a href="https://flypush.research.bcm.edu/lab/hugo/index.html" target="_blank" rel="ugc noopener noreferrer">Hugo Bellen</a></p></li><li><p><a href="https://www.texaschildrens.org/duncan-nri" target="_blank" rel="ugc noopener noreferrer">Jan and Dan Duncan Neurological Research Institute</a></p></li><li><p><a href="https://genesdev.cshlp.org/content/16/11/1314.short" target="_blank" rel="ugc noopener noreferrer">Hugoによるレビュー</a></p></li><li><p><a href="https://emr.wicmb.cornell.edu/" target="_blank" rel="ugc noopener noreferrer">Scott Emr</a></p></li><li><p><a href="https://www.bs.s.u-tokyo.ac.jp/~hassei/" target="_blank" rel="ugc noopener noreferrer">武田洋幸先生</a></p></li><li><p><a href="https://researchmap.jp/tetsuyatabata" target="_blank" rel="ugc noopener noreferrer">多羽田哲也先生</a></p></li><li><p><a href="https://www2.rikkyo.ac.jp/web/cells/" target="_blank" rel="ugc noopener noreferrer">後藤聡先生</a></p></li><li><p>Retromer ComplexとWnt signalingに関する論文(４本じゃなくて５本でした：Dev Cell x3 + NCB x2) <a href="https://linkinghub.elsevier.com/retrieve/pii/S1534-5807(07)00478-9" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.cell.com/developmental-cell/fulltext/S1534-5807(07)00481-9" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.cell.com/developmental-cell/fulltext/S1534-5807(07)00480-7" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://www.nature.com/articles/ncb1687" target="_blank" rel="ugc noopener noreferrer">4</a> <a href="https://www.nature.com/articles/ncb1678" target="_blank" rel="ugc noopener noreferrer">5</a></p></li><li><p><a href="https://www.janelia.org/people/gerry-rubin" target="_blank" rel="ugc noopener noreferrer">Gerry Rubin</a></p></li><li><p><a href="https://www.hhmi.org/scientists/allan-c-spradling" target="_blank" rel="ugc noopener noreferrer">Allan Spradling</a></p></li><li><p><a href="https://www.hhmi.org/scientists/thomas-r-cech" target="_blank" rel="ugc noopener noreferrer">Thomas Cech</a></p></li><li><p>Seymour Benzer追悼記事 <a href="https://www.nature.com/articles/451139a" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.science.org/doi/10.1126/science.1154050" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p><a href="https://www.nobelprize.org/prizes/medicine/1933/morgan/biographical/" target="_blank" rel="ugc noopener noreferrer">Thomas Hunt Morgan</a></p></li><li><p><a href="https://collections.libraries.indiana.edu/muller/exhibits/show/fly-room/page-1" target="_blank" rel="ugc noopener noreferrer">ハエ研究の黎明期</a></p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(15)01128-9" target="_blank" rel="ugc noopener noreferrer">メンデルによる遺伝子の提唱と再発見</a></p></li><li><p><a href="https://link.springer.com/article/10.1007/BF02156638" target="_blank" rel="ugc noopener noreferrer">津田梅子先生がMorganのところでやった仕事</a></p></li><li><p><a href="https://ja.wikipedia.org/wiki/%E3%83%A1%E3%83%B3%E3%83%87%E3%83%AB%E3%81%AE%E6%B3%95%E5%89%87" target="_blank" rel="ugc noopener noreferrer">メンデルの法則</a></p></li><li><p><a href="https://www.nobelprize.org/prizes/medicine/1946/muller/facts/" target="_blank" rel="ugc noopener noreferrer">Hermann Muller</a></p></li><li><p><a href="https://www.science.org/doi/10.1126/science.66.1699.84" target="_blank" rel="ugc noopener noreferrer">放射線による遺伝子の破壊・改変を発見</a></p></li><li><p>Marie Curie<a href="https://note.com/medicalview/n/n0b6ff6876b60" target="_blank" rel="ugc noopener noreferrer">の死因</a></p></li><li><p><a href="https://www.ncbi.nlm.nih.gov/books/NBK10123/#:~:text=The%20split%20between%20embryology%20and,been%20met%20by%20the%20geneticists:" target="_blank" rel="ugc noopener noreferrer">発生生物学者と遺伝学者は仲が悪かった</a></p></li><li><p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0070215310920012?via%3Dihub" target="_blank" rel="ugc noopener noreferrer">最初のNotchミュータントの欠けている翅</a></p></li><li><p><a href="https://link.springer.com/article/10.1007/BF00848482" target="_blank" rel="ugc noopener noreferrer">HomozygousだとNeurogenic phenotype</a></p></li><li><p><a href="https://learn.genetics.utah.edu/content/basics/hoxgenes/" target="_blank" rel="ugc noopener noreferrer">AntennapediaとUltrabithorax</a></p></li><li><p><a href="https://www.pnas.org/doi/10.1073/pnas.71.3.708" target="_blank" rel="ugc noopener noreferrer">ハエの記憶に関する最初の報告</a></p></li><li><p><a href="https://www.jstor.org/stable/65976" target="_blank" rel="ugc noopener noreferrer">この系をつかった最初のL&Mの変異体、dunceの論文(cAMPの分解酵素)</a></p></li><li><p><a href="https://www.pnas.org/doi/10.1073/pnas.68.9.2112" target="_blank" rel="ugc noopener noreferrer">サーカディアンリズムのperiod変異体の論文</a></p></li><li><p><a href="https://www.nature.com/articles/351583a0" target="_blank" rel="ugc noopener noreferrer">ShibireはDynaminに関する変異体</a></p></li><li><p><a href="https://www.jneurosci.org/content/21/5/1523.long" target="_blank" rel="ugc noopener noreferrer">Kir2.1</a></p></li><li><p><a href="https://www.jneurosci.org/content/26/2/479.long" target="_blank" rel="ugc noopener noreferrer">NaChBac</a></p></li><li><p>遺伝学的手法を用いて<a href="https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(11)00872-5" target="_blank" rel="ugc noopener noreferrer">ハエの神経活動を操作する(リンク先Table2)</a></p></li><li><p><a href="https://genetics-gsa.org/drosophila/" target="_blank" rel="ugc noopener noreferrer">GSAによるショウジョウバエの学会</a></p></li><li><p><a href="https://meetings.cshl.edu/meetings.aspx?meet=DROS" target="_blank" rel="ugc noopener noreferrer">CSHLのNeurobiology of Drosophila</a></p></li><li><p><a href="https://www.janelia.org/you-janelia/conferences/conferences" target="_blank" rel="ugc noopener noreferrer">Janeliaのconference</a></p></li><li><p><a href="https://neuroradio.tokyo/2024/11/02/81-through-the-wire/" target="_blank" rel="ugc noopener noreferrer">NRでショウジョウバエを扱った回</a></p></li><li><p><a href="https://ja.wikipedia.org/wiki/%E9%81%BA%E4%BC%9D%E5%AD%A6%E7%9A%84%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%8B%E3%83%B3%E3%82%B0" target="_blank" rel="ugc noopener noreferrer">Forward genetics(順遺伝学)とReverse genetics(逆遺伝学)</a></p></li><li><p>C<a href="https://en.wikipedia.org/wiki/Forward_genetics" target="_blank" rel="ugc noopener noreferrer">hemical mutagenesisではEMSやENUがよく用いられる</a></p></li><li><p><a href="https://linkinghub.elsevier.com/retrieve/pii/0092-8674(90)90413-9" target="_blank" rel="ugc noopener noreferrer">armadillo (arm)＝ハエのβ-Catenin</a> </p></li><li><p><a href="https://www.nobelprize.org/prizes/medicine/1995/nusslein-volhard/biographical/" target="_blank" rel="ugc noopener noreferrer">Christiane Nüsslein-Volhard</a></p></li><li><p><a href="https://www.nobelprize.org/prizes/medicine/1995/wieschaus/facts/" target="_blank" rel="ugc noopener noreferrer">Eric Wieschaus</a></p></li><li><p><a href="https://www.annualreviews.org/content/journals/10.1146/annurev-cellbio-113015-023138" target="_blank" rel="ugc noopener noreferrer">The Heidelberg screen回顧録</a></p></li><li><p><a href="https://www.cell.com/fulltext/S0896-6273(00)80701-1" target="_blank" rel="ugc noopener noreferrer">MARCM</a></p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(00)81826-7" target="_blank" rel="ugc noopener noreferrer">利根川先生のCaMKII-Creを用いたconditional KO</a> (訂正：CaMKIIをcKOしたんじゃなくて、CaMKII-Creを用いて別の遺伝子をcKOしてましたね。 by 山)</p></li><li><p>Flp/FRTとEMSを組み合わせることによるモザイク・スクリーニングの<a href="https://journals.biologists.com/dev/article-abstract/117/4/1223/37629/Analysis-of-genetic-mosaics-in-developing-and" target="_blank" rel="ugc noopener noreferrer">初出論文</a> <a href="https://www.nature.com/articles/nrg751" target="_blank" rel="ugc noopener noreferrer">レビュー</a></p></li><li><p>ハエのElectroretinogram(ERG) <a href="https://www.nature.com/articles/222351a0" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.nature.com/articles/222354a0" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p>ｍ<a href="https://www.terumozaidan.or.jp/labo/class/12/interview02.html" target="_blank" rel="ugc noopener noreferrer">usashiとハエの感覚毛の４細胞感覚ユニット</a></p></li><li><p>岡野先生らによるm<a href="https://www.cell.com/neuron/abstract/0896-6273(94)90460-X" target="_blank" rel="ugc noopener noreferrer">usashi発見</a></p></li><li><p><a href="https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00700/full" target="_blank" rel="ugc noopener noreferrer">博士の時にやったスクリーニング</a></p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(14)01113-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867414011131%3Fshowall%3Dtrue" target="_blank" rel="ugc noopener noreferrer">結果をヒト希少疾患と結びつけたCell論文</a></p></li><li><p>ApoE2とE4: 逆でした (by 山)</p></li><li><p><a href="https://blogs.bcm.edu/2023/04/13/from-the-labs-baylor-collegef-of-medicine-human-genome-sequencing-center-celebrates-20-years-since-the-completion-of-the-human-genome-sequencing-project/" target="_blank" rel="ugc noopener noreferrer">ヒトゲノム計画におけるBaylorの貢献</a></p></li><li><p><a href="https://www.genome.gov/10001688/international-hapmap-project" target="_blank" rel="ugc noopener noreferrer">HapMap project</a></p></li><li><p><a href="https://www.internationalgenome.org/1000-genomes-summary/" target="_blank" rel="ugc noopener noreferrer">1000 Genomes project</a></p></li><li><p><a href="https://www.genome.gov/Funded-Programs-Projects/NHGRI-Genome-Sequencing-Program/Centers-for-Mendelian-Genomics-CMG" target="_blank" rel="ugc noopener noreferrer">Center for Mendelian Genomics</a></p></li><li><p><a href="https://www.bcm.edu/people-search/richard-gibbs-22009" target="_blank" rel="ugc noopener noreferrer">Richard Gibbs</a></p></li><li><p><a href="https://www.lupskilaboratory.org/" target="_blank" rel="ugc noopener noreferrer">James Lupski</a></p></li><li><p><a href="https://en.wikipedia.org/wiki/Synteny" target="_blank" rel="ugc noopener noreferrer">Synteny(シンテニー)</a></p></li><li><p><a href="https://ja.wikipedia.org/wiki/%E9%81%BA%E4%BC%9D%E7%9A%84%E7%9B%B8%E8%A3%9C%E6%80%A7" target="_blank" rel="ugc noopener noreferrer">Complementation test(相補性検定)</a></p></li><li><p><a href="https://www.nature.com/articles/nn1910" target="_blank" rel="ugc noopener noreferrer">LiqinのMARCM EMS Screenの例</a></p></li><li><p><a href="https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.22723" target="_blank" rel="ugc noopener noreferrer">Hippo signaling pathway レビュー</a></p></li><li><p>このPathwayのコアのhippoという遺伝子は４つのラボで同時期にFLP/FRTスクリーニングなどを通じてみつかりました（Cell２本、NCB２本） <a href="https://www.cell.com/cell/fulltext/S0092-8674(03)00549-X" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.cell.com/cell/fulltext/S0092-8674(03)00557-9" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://www.nature.com/articles/ncb1050" target="_blank" rel="ugc noopener noreferrer">3</a> <a href="https://www.nature.com/articles/ncb1051" target="_blank" rel="ugc noopener noreferrer">4</a></p></li><li><p>ハエのin vivo RNAiのライブラリ <a href="https://fgr.hms.harvard.edu/fly-in-vivo-rnai" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://shop.vbc.ac.at/vdrc_store/rnai-info" target="_blank" rel="ugc noopener noreferrer">2</a> <a href="https://shigen.nig.ac.jp/fly/nigfly/rnaiListAction.do?browseOrSearch=browse" target="_blank" rel="ugc noopener noreferrer">3</a></p></li><li><p>RNAiとEMSで見えてくる遺伝子が違う：<a href="https://www.cell.com/cms/10.1016/j.cell.2014.09.002/asset/2f6954ee-20d3-476d-9261-1ba3d3f1e9f0/main.assets/gr2_lrg.jpg" target="_blank" rel="ugc noopener noreferrer">Cell論文のFig. 2</a></p></li><li><p>CRISPRも含めて、Mammalの例 <a href="https://www.nature.com/articles/nbt.3567" target="_blank" rel="ugc noopener noreferrer">1</a> <a href="https://www.cell.com/cell-systems/fulltext/S2405-4712(16)30291-5" target="_blank" rel="ugc noopener noreferrer">2</a></p></li><li><p><a href="https://www.nature.com/articles/ng1099_185" target="_blank" rel="ugc noopener noreferrer">Rett Syndromeの原因遺伝子はMECP2</a></p></li><li><p><a href="https://www.bcm.edu/research/faculty-labs/huda-zoghbi-lab" target="_blank" rel="ugc noopener noreferrer">Huda Zoghbi</a></p></li><li><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(15)01129-0" target="_blank" rel="ugc noopener noreferrer">ハエ遺伝子のヒト化</a></p></li><li><p><a href="https://elifesciences.org/articles/35574" target="_blank" rel="ugc noopener noreferrer">T2A-GAL4</a></p></li><li><p><a href="https://elifesciences.org/articles/76077" target="_blank" rel="ugc noopener noreferrer">Kozak-GAL4</a></p></li><li><p><a href="https://en.wikipedia.org/wiki/Muller%27s_morphs" target="_blank" rel="ugc noopener noreferrer">Mutationの機能的分類(Muller's morphs)</a></p></li><li><p><a href="https://undiagnosed.hms.harvard.edu/" target="_blank" rel="ugc noopener noreferrer">Undiagnosed Diseases Network(UDN)</a></p></li><li><p><a href="https://commonfund.nih.gov/" target="_blank" rel="ugc noopener noreferrer">NIH Commonfund</a></p></li><li><p><a href="https://braininitiative.nih.gov/" target="_blank" rel="ugc noopener noreferrer">BRAIN initiative</a></p></li><li><p><a href="https://undiagnosed.hms.harvard.edu/research/model-organisms-phase-ii/" target="_blank" rel="ugc noopener noreferrer">UDN Model Organisms Screening Center</a></p></li><li><p><a href="https://plaza.umin.ac.jp/irud/" target="_blank"
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